Review of medical abortion using mifepristone in combination with a prostaglandin analogue

被引:101
作者
Fiala, Christian
Gemzell-Danielsson, Kristina
机构
[1] Gynmed Clin, A-1150 Vienna, Austria
[2] Karolinska Inst, Div Obstet & Gynaecol, Dept Woman & Child Hlth, SE-17176 Stockholm, Sweden
关键词
medical abortion; mifepristone; misoprostol; gemeprost; review;
D O I
10.1016/j.contraception.2006.03.018
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Induced abortion is still a major health problem in the world and the most frequently performed intervention in obstetrics and gynecology with an estimated total of 46 million worldwide each year. Medical abortion with mifepristone and prostaglandin was first introduced in 1988 and is now approved in 31 countries. This combination of drugs has recently been included in the List of Essential Medicines by the World Health Organisation. The present review summarizes the development, physiology and the development of the currently used regimens. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:66 / 86
页数:21
相关论文
共 200 条
[21]   Double-blind randomized trial of mifepristone in combination with vaginal gemeprost or misoprostol for induction of abortion up to 63 days gestation [J].
Bartley, J ;
Brown, A ;
Elton, R ;
Baird, DT .
HUMAN REPRODUCTION, 2001, 16 (10) :2098-2102
[22]   Mifepristone and misoprostol for medical termination of pregnancy: the effectiveness of a flexible regimen [J].
Basu, R ;
Gundlach, T ;
Tasker, M .
JOURNAL OF FAMILY PLANNING AND REPRODUCTIVE HEALTH CARE, 2003, 29 (03) :139-141
[23]  
BAULIEU EE, 1991, ISS BIOM M, V15, P127
[24]  
BAULIEU EE, 1985, B ACAD NAT MED PARIS, V169, P1191
[25]   CONTRAGESTION AND OTHER CLINICAL-APPLICATIONS OF RU-486, AN ANTIPROGESTERONE AT THE RECEPTOR [J].
BAULIEU, EE .
SCIENCE, 1989, 245 (4924) :1351-1357
[26]   Mifepristone does not induce cervical softening in non-pregnant women [J].
Ben-Chetrit, A ;
Eldar-Geva, T ;
Lindenberg, T ;
Farhat, M ;
Shimonovitz, S ;
Zacut, D ;
Gelber, H ;
Sitruk-Ware, R ;
Spitz, IM .
HUMAN REPRODUCTION, 2004, 19 (10) :2372-2376
[27]   A SINGLE AMINO-ACID THAT DETERMINES THE SENSITIVITY OF PROGESTERONE RECEPTORS TO RU486 [J].
BENHAMOU, B ;
GARCIA, T ;
LEROUGE, T ;
VERGEZAC, A ;
GOFFLO, D ;
BIGOGNE, C ;
CHAMBON, P ;
GRONEMEYER, H .
SCIENCE, 1992, 255 (5041) :206-209
[28]   THE ANTIPROGESTATIONAL AGENT RU-486 AS AN ABORTIFACIENT IN EARLY HUMAN-PREGNANCY - A COMPARISON OF 3 DOSE REGIMENS [J].
BIRGERSON, L ;
ODLIND, V .
CONTRACEPTION, 1988, 38 (04) :391-400
[29]  
BIRGERSON L, 1987, FERTIL STERIL, V48, P565
[30]  
Blanchard K, 2000, J Am Med Womens Assoc (1972), V55, P189