2β-carbomethoxy-3β-(4-and 2-[18F]fluoromethylphenyl)tropanes:: Specific probes for in vivo quantification of central dopamine transporter sites

被引：13

作者：

Stout, D

Petric, A

Satyamurthy, N

Nguyen, Q

Huang, SC

Namavari, M

Barrio, JR ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Div Nucl Med, Los Angeles, CA 90095 USA

[2] Lab Struct Biol & Mol Med, Los Angeles, CA USA

[3] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana, Slovenia

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1999年 / 26卷 / 08期

关键词：

2 beta-carbomethoxy-3 beta-(4-[F-18]fluoromethylphenyl)tropane (p-FWIN); 2 beta-carbomethoxy-3 beta(2-[F-18]fluoromethylphenyl)tropane (o-FWIN); positron emission tomography; dopamine transporter; central dopaminergic system;

D O I：

10.1016/S0969-8051(99)00073-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Dopamine reuptake transporter binding kinetics of 2 beta-carbomethoxy-3 beta-(4-[F-18]fluoromethylphenyl)tropane (p-FWIN) and 2 beta-carbomethoxy-3 beta-(2-[F-18]fluoromethylphenyl)tropane (o-FWIN) were determined in vervet monkeys using positron emission tomography (PET). Ligand localization was rapid and specific to the striatum with kinetic estimates comparable with those of C-11-labeled WIN 35,428 (CWIN). Binding was more specific with p-FWIN than with CWIN or o-FWIN. The relatively longer half-life of the F-18 radiolabel enabled longer acquisition times with p-FWIN, resulting in less variability in the kinetic estimates. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：897 / 903

页数：7

共 32 条

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