Selective phosphitylation of the primary hydroxyl group in unprotected carbohydrates and nucleosides

被引：14

作者：

Graham, SM ^{[1
]}

Pope, SC

机构：

[1] St Johns Univ, Dept Chem, Jamaica, NY 11439 USA

[2] Oklahoma State Univ, Dept Chem, Stillwater, OK 74075 USA

[3] CUNY York Coll, NMR Ctr, Jamaica, NY 11451 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 05期

关键词：

D O I：

10.1021/ol990769k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Carbohydrates and nucleosides containing a phosphate at the less-hindered primary hydroxyl group are often prepared using a protection/deprotection strategy, Herein we report that the phosphoramidite method can be used to selectively incorporate phosphorus at the primary hydroxyl group of O-unprotected carbohydrates and nucleosides; in situ oxidation of the resulting phosphite triester yields the phosphate triester.

引用

页码：733 / 736

页数：4

共 27 条

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