Selective phosphitylation of the primary hydroxyl group in unprotected carbohydrates and nucleosides

被引:14
作者
Graham, SM [1 ]
Pope, SC
机构
[1] St Johns Univ, Dept Chem, Jamaica, NY 11439 USA
[2] Oklahoma State Univ, Dept Chem, Stillwater, OK 74075 USA
[3] CUNY York Coll, NMR Ctr, Jamaica, NY 11451 USA
关键词
D O I
10.1021/ol990769k
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Carbohydrates and nucleosides containing a phosphate at the less-hindered primary hydroxyl group are often prepared using a protection/deprotection strategy, Herein we report that the phosphoramidite method can be used to selectively incorporate phosphorus at the primary hydroxyl group of O-unprotected carbohydrates and nucleosides; in situ oxidation of the resulting phosphite triester yields the phosphate triester.
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页码:733 / 736
页数:4
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