A chromatin-associated protein is encoded in a genomic region highly conserved in the Plasmodium genus

被引:17
作者
Birago, C
Pace, T
Barca, S
Picci, L
Ponzi, M
机构
[1] IST SUPER SANITA, LAB BIOL CELLULARE, I-00161 ROME, ITALY
[2] IST SUPER SANITA, IMMUNOL LAB, I-00161 ROME, ITALY
关键词
Plasmodium; chromatin; nucleosome assembly proteins;
D O I
10.1016/0166-6851(96)02680-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A single copy gene, pbB7, encoding a putative 26 kDa acidic protein has been isolated from Plasmodium berghei and appears to be part of a genomic region well conserved within the Plasmodium genus. The deduced amino acid sequence exhibits significant blocks of similarity with nucleosome assembly proteins from yeast and man. The nuclear localization of the natural protein and its close association with chromatin during the entire erythrocytic cycle of the parasite have been demonstrated using specific monoclonal antibodies against the pbB7 product expressed in Escherichia coli. These results suggest an involvement of this nuclear factor in the dynamics of chromatin packaging.
引用
收藏
页码:193 / 202
页数:10
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