Uncovering stemness

被引：10

作者：

Bilodeau, Melanie

Sauvageau, Guy

机构：

[1] IRIC, Lab Mol Genet Stem Cells, Montreal, PQ H3C 3J7, Canada

[2] Maisonneuve Rosemont Hosp, Cell Bank, Dept Med, Montreal, PQ, Canada

[3] Maisonneuve Rosemont Hosp, Cell Bank, Div Hematol & Leukemia, Montreal, PQ, Canada

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 10期

关键词：

D O I：

10.1038/ncb1006-1048

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Understanding how self-renewal and pluripotency - two key characteristics of stem cells - are controlled may allow generation of stem cell lines from somatic tissues, thus avoiding the ethically contentious need to derive them from embryos. A step forward in this understanding was recently taken by two teams, who exploited recombinant retroviruses in gain-and-loss of function experiments to characterize candidate transcription factors with the potential to regulate 'stemness'.

引用

页码：1048 / 1049

页数：2

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