Non-cryogenic metalation of aryl bromides bearing proton donating groups: formation of a stable magnesio-intermediate

被引：26

作者：

Kato, S ^{[1
]}

Nonoyama, N ^{[1
]}

Tomimoto, K ^{[1
]}

Mase, T ^{[1
]}

机构：

[1] Banyu Pharmaceut Co Ltd, Labs Technol Dev, Proc R&D, Proc Res, Okazaki, Aichi 4440858, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(02)01747-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bromine-metal exchange of o-bromobenzoic acid (1) with Bu2Mg followed by n-BuLi was successfully carried out at non-cryogenic temperature (>-20degreesC), and gave a stabilized metal species which smoothly reacted with several electrophiles. This methodology expanded to several other bromides bearing proton donating groups (PDGs). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7315 / 7317

页数：3

共 17 条

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