Role of the endocannabinoid system in Alzheimer's disease:: New perspectives

被引：56

作者：

Pazos, MR ^{[1
]}

Núñez, E ^{[1
]}

Benito, C ^{[1
]}

Tolón, RM ^{[1
]}

Romero, J ^{[1
]}

机构：

[1] Fdn Hosp Alcorcon, Lab Apoyo Invest, Madrid 28922, Spain

来源：

LIFE SCIENCES | 2004年 / 75卷 / 16期

关键词：

endocannabinoids; receptors; Alzheimer's disease; inflammation; Glia;

D O I：

10.1016/j.lfs.2004.03.026

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The role of the endocannabinoid system in several diseases is currently under intense study. Among these, Alzheimer's disease may be a new promising area of research. We have recently reported the existence of profound changes in the location and density of several elements of this system in Alzheimer's disease tissue samples, indicating that a non-neuronal endocannabinoid system is up-regulated in activated glia. Additional data from other groups suggest that glial cells may be important elements in the regulation of endocannabinoid system activity, both in health as in disease. Some of these aspects are briefly discussed in the present review. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1907 / 1915

页数：9

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