Apolipoprotein E and Alzheimer's disease

被引：376

作者：

Strittmatter, WJ ^{[1
]}

Roses, AD ^{[1
]}

机构：

[1] DUKE UNIV, MED CTR, JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR, DEPT NEUROBIOL, DURHAM, NC 27710 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 1996年 / 19卷

关键词：

neurofibrillary tangles; neuritic plaques; tau; microtubules;

D O I：

10.1146/annurev.ne.19.030196.000413

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease. The APOE4 allele increases the probability of disease at an earlier age. In contrast, the APOE3 and APOE2 alleles decrease the probability of disease and increase the age of onset. Therefore the metabolism of apolipoprotein E is relevant to Alzheimer's disease. Isoform-specific interactions of apolipoprotein E with other molecules may determine the rate of disease expression through molecular pathways that appear unique to the disease. In addition, some isoform-specific interactions of apolipoprotein E have been demonstrated with the defining pathological lesions of Alzheimer's disease, the neurofibrillary tangle and neuritic plaque. Several hypotheses of disease pathogenesis are now based on the relevance of apolipoprotein E.

引用

页码：53 / 77

页数：25

共 89 条

[31] PLAQUE-ONLY ALZHEIMER-DISEASE IS USUALLY THE LEWY BODY VARIANT, AND VICE-VERSA [J].