Immunogenic and tolerogenic cell death

被引:915
作者
Green, Douglas R. [1 ]
Ferguson, Thomas [2 ]
Zitvogel, Laurence [3 ,4 ,5 ,6 ]
Kroemer, Guido [5 ,6 ,7 ]
机构
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
[2] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
[3] INSERM, U805, F-94805 Villejuif, France
[4] Ctr Clin Invest BT507, F-94805 Villejuif, France
[5] Inst Gustave Roussy, F-94805 Villejuif, France
[6] Univ Paris 11, Fac Paris Sud, F-94805 Le Kremlin Bicetre, France
[7] INSERM, U848, F-94805 Villejuif, France
基金
美国国家卫生研究院;
关键词
CD8(+) T-CELLS; APOPTOTIC CELLS; DENDRITIC CELL; IMMUNE-SYSTEM; TGF-BETA; CALRETICULIN EXPOSURE; DEPENDENT CLEARANCE; CROSS-PRESENTATION; LYMPHOID-CELLS; TUMOR-CELLS;
D O I
10.1038/nri2545
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The immune system is routinely exposed to dead cells during normal cell turnover, injury and infection. Mechanisms must exist to discriminate between different forms of cell death to correctly eliminate pathogens and promote healing while avoiding responses to self, which can result in autoimmunity. However, an effective immune response against host tissue is often needed to eliminate tumours following treatment with chemotherapeutic agents that trigger tumour cell death. Consequently, a central problem in immunology is to understand how the immune system determines whether cell death is immunogenic, tolerogenic or 'silent'.
引用
收藏
页码:353 / 363
页数:11
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