A practical synthesis of (R)- and (S)-3-amino-3,4-dihydro-1-H-quinolin-2-one

被引：16

作者：

Hulin, B ^{[1
]}

Lopaze, MG ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Groton, CT 06340 USA

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 12期

关键词：

D O I：

10.1016/j.tetasy.2004.05.013

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Asymmetric alkylation of N-(diphenylmethylene)glycine tert-butyl ester with 2-nitrobenzyl bromide followed by reductive cyclization provides (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one in high yield and high enantiomeric excess. (C) 2004 Published by Elsevier Ltd.

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页码：1957 / 1958

页数：2

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