Interpenetrating Polymer Networks of Poly(N-vinylacetamide) and Poly(acrylic acid) Applied to Novel Amphiphilic Drug Release Substrates with Mechanically Modified Strengths

被引：13

作者：

Ajiro, Hiroharu ^{[1
,2
]}

Takemoto, Yukie ^{[1
]}

Akashi, Mitsuru ^{[1
,2
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Ctr Adv Med Engn & Informat, Suita, Osaka 5650871, Japan

来源：

CHEMISTRY LETTERS | 2009年 / 38卷 / 04期

关键词：

HYDROGELS; VINYLACETAMIDE;

D O I：

10.1246/cl.2009.368

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Gels with interpenetrating polymer networks were prepared with N-vinylacetamide (NVA) and acrylic acid (AAc) as novel substrates for transdermal therapeutic systems. The gelation of NVA at 1 M in AAc gel Sustained the amphiphilic character, and a poorly water-soluble drug was kept in the gel with ethanol as solvent. Mechanical strengths were five times larger in value than those of simple poly(N-vinylacetamide) gels.

引用

页码：368 / 369

页数：2

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