Interaction between chlorophyll a and β-cyclodextrin derivatives in aqueous solutions -: Spectroscopic and calorimetric study

被引：18

作者：

Agostiano, A

Catucci, L

Castagnolo, M

Colangelo, D

Cosma, P

Fini, P

Della Monica, M

机构：

[1] CNR, Ctr Studi Chim Fis Interaz Luce Mat, I-70126 Bari, Italy

[2] Univ Bari, Dipartmento Chim, I-70126 Bari, Italy

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2002年 / 70卷 / 01期

关键词：

chlorophyll a; cyclodextrins; photodynamic therapy;

D O I：

10.1023/A:1020601600086

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Cyclodextrins (CDs) are widely used as delivery systems of poorly water soluble drugs in pharmacological applications. The delivery system produces an increase of aqueous solubility of the drug and significant modifications in its physico-chemical and pharmacological properties. In this paper we report the results of our study on aqueous solutions of chlorophyll a, a natural pigment useful as sensitizer in the photodynamic therapy, and two CDs: hydroxypropyl-beta-cyclodextrin and heptakis(2,6-di-O-methyl)-beta-cyclodextrin. The interactions between chlorophyll and CDs and the effect produced by the presence of the CDs on the aggregation of chlorophyll were studied by calorimetric and UV-Vis spectrophotometric measurements respectively.

引用

页码：115 / 122

页数：8

共 18 条

[1]

AGOSTIANO A, UNPUB J PHOTOCHEM B

[2] STOICHIOMETRIC DETERMINATION OF CHLOROPHYLL-A - WATER AGGREGATES AND PHOTOSYNTHESIS - SYMBIOTIC ROLES OF MAGNESIUM ATOM AND RING-V CYCLOPENTANONE GROUP IN STRUCTURAL AND PHOTO-CHEMICAL PROPERTIES OF CHLOROPHYLL-A MONOHYDRATE AND DIHYDRATE [J].