Conformationally restricted carbohydrate-modified nucleic acids and antisense technology

被引：136

作者：

Herdewijn, P ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1489卷 / 01期

关键词：

pyranose nucleoside; hexitol nucleoside; conformationally restricted nucleoside; carbohydrate modification; preorganization; hybridization;

D O I：

10.1016/S0167-4781(99)00152-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study of conformationally restricted carbohydrate modified nucleic acids has given new insights into the concept of the antisense technology. We learned to understand the structural requirements of a modified nucleic acid to function as steric blocker for RNA. Several of the physicochemical and conformational factors influencing duplex stabilization are analyzed with respect to their relative importance for the antisense field. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：167 / 179

页数：13

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