The cutting-edge of mammalian development; How the embryo makes teeth

被引：409

作者：

Tucker, A ^{[1
]}

Sharpe, P ^{[1
]}

机构：

[1] Guys Hosp, Univ London Kings Coll, Inst Dent, Dept Craniofacial Dev, London SE1 9RT, England

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 07期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1038/nrg1380

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A wealth of information has recently become available on the molecular signals that are required to form and pattern the dentition in the mouse, shedding light on how important decisions about tooth shape, tooth number and cusp (cone-shaped prominence) number are generated. This information, which has been gleaned principally from knockout mice and manipulation of organ cultures, has been used to identify the genes and developmental processes that underlie the many human disorders in which tooth development is defective. Mouse models of several of these syndromes have also indicated ways in which such conditions could be treated.

引用

页码：499 / 508

页数：10

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