Site-specific scission of lambda phage genomic DNA by Ce(IV)/EDTA-based artificial restriction DNA cutter

被引：8

作者：

Yamamoto, Yoji ^{[1
]}

Miura, Kazuyuki ^{[1
]}

Komiyama, Makoto ^{[1
]}

机构：

[1] Univ Tokyo, Adv Sci & Technol Res Ctr, Meguro Ku, Tokyo 1538904, Japan

来源：

CHEMISTRY LETTERS | 2006年 / 35卷 / 06期

关键词：

D O I：

10.1246/cl.2006.594

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lambda phage genomic DNA (48502 base pairs) was site-selectively hydrolyzed by artificial restriction DNA cutter (ARCUT), which we have developed by combining Ce(IV)/EDTA and pseudo-complementary PNA. PNA satisfactorily invaded lambda DNA and activated the target site for the scission by Ce(IV)/EDTA.

引用

页码：594 / 595

页数：2

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