共 33 条
Intracellularly inducible, ubiquitin hydrolase-insensitive tandem ubiquitins inhibit the 26S proteasome activity and cell division
被引:12
作者:

Saeki, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan

Isono, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan

Oguchi, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan

Shimada, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan

Sone, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan

Kawahara, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan

Yokosawa, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan

Toh-e, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan
机构:
[1] Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan
[2] Hokkaido Univ, Dept Biochem, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600821, Japan
关键词:
hydrolase resistant-tandem ubiquitin;
inhibitor;
proteasome;
proteolysis;
yeast;
D O I:
10.1266/ggs.79.77
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
We constructed polyubiquitin derivatives that contain a tandem repeat of ubiquitins and were insensitive to ubiquitin hydrolases. They were designated tandem ubiquitin (tUb) with the number of repeats, such as tUb2. When tUbs were expressed under the control of the GAL1 promoter in the wild-type yeast strain, growth was strongly inhibited. Under these conditions, the degradation of N-end rule substrates, a UFD substrate and Gcn4 was inhibited, indicating that the tUb inhibits 26S proteasome activity. Consistent with this, tUb binds to the 26S proteasome. We showed that tUb inhibited the in vitro degradation of polyubiquitinylated Sic1 by the 26S proteasome. When tUB6 messenger RNA was injected into Xenopus embryos, cell division was inhibited, suggesting that tUb can be used as a versatile inhibitor of the 26S proteasome.
引用
收藏
页码:77 / 86
页数:10
相关论文
共 33 条
[1]
INVIVO HALF-LIFE OF A PROTEIN IS A FUNCTION OF ITS AMINO-TERMINAL RESIDUE
[J].
BACHMAIR, A
;
FINLEY, D
;
VARSHAVSKY, A
.
SCIENCE,
1986, 234 (4773)
:179-186

BACHMAIR, A
论文数: 0 引用数: 0
h-index: 0

FINLEY, D
论文数: 0 引用数: 0
h-index: 0

VARSHAVSKY, A
论文数: 0 引用数: 0
h-index: 0
[2]
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors
[J].
Bogyo, M
;
McMaster, JS
;
Gaczynska, M
;
Tortorella, D
;
Goldberg, AL
;
Ploegh, H
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1997, 94 (13)
:6629-6634

Bogyo, M
论文数: 0 引用数: 0
h-index: 0
机构: MIT,CTR CANC RES,DEPT BIOL,CAMBRIDGE,MA 02139

McMaster, JS
论文数: 0 引用数: 0
h-index: 0
机构: MIT,CTR CANC RES,DEPT BIOL,CAMBRIDGE,MA 02139

Gaczynska, M
论文数: 0 引用数: 0
h-index: 0
机构: MIT,CTR CANC RES,DEPT BIOL,CAMBRIDGE,MA 02139

Tortorella, D
论文数: 0 引用数: 0
h-index: 0
机构: MIT,CTR CANC RES,DEPT BIOL,CAMBRIDGE,MA 02139

Goldberg, AL
论文数: 0 引用数: 0
h-index: 0
机构: MIT,CTR CANC RES,DEPT BIOL,CAMBRIDGE,MA 02139

Ploegh, H
论文数: 0 引用数: 0
h-index: 0
机构: MIT,CTR CANC RES,DEPT BIOL,CAMBRIDGE,MA 02139
[3]
A MULTIUBIQUITIN CHAIN IS CONFINED TO SPECIFIC LYSINE IN A TARGETED SHORT-LIVED PROTEIN
[J].
CHAU, V
;
TOBIAS, JW
;
BACHMAIR, A
;
MARRIOTT, D
;
ECKER, DJ
;
GONDA, DK
;
VARSHAVSKY, A
.
SCIENCE,
1989, 243 (4898)
:1576-1583

CHAU, V
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

TOBIAS, JW
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

BACHMAIR, A
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

MARRIOTT, D
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

ECKER, DJ
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

GONDA, DK
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

VARSHAVSKY, A
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139
[4]
Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase
[J].
Chi, Y
;
Huddleston, MJ
;
Zhang, XL
;
Young, RA
;
Annan, RS
;
Carr, SA
;
Deshaies, RJ
.
GENES & DEVELOPMENT,
2001, 15 (09)
:1078-1092

Chi, Y
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Div Biol, Pasadena, CA 91125 USA

Huddleston, MJ
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Div Biol, Pasadena, CA 91125 USA

Zhang, XL
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Div Biol, Pasadena, CA 91125 USA

Young, RA
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Div Biol, Pasadena, CA 91125 USA

Annan, RS
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Div Biol, Pasadena, CA 91125 USA

Carr, SA
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Div Biol, Pasadena, CA 91125 USA

Deshaies, RJ
论文数: 0 引用数: 0
h-index: 0
机构:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH, Div Biol, Pasadena, CA 91125 USA
[5]
Structure and functions of the 20S and 26S proteasomes
[J].
Coux, O
;
Tanaka, K
;
Goldberg, AL
.
ANNUAL REVIEW OF BIOCHEMISTRY,
1996, 65
:801-847

Coux, O
论文数: 0 引用数: 0
h-index: 0
机构:
TOKYO METROPOLITAN INST MED SCI, BUNKYO KU, TOKYO 113, JAPAN TOKYO METROPOLITAN INST MED SCI, BUNKYO KU, TOKYO 113, JAPAN

Tanaka, K
论文数: 0 引用数: 0
h-index: 0
机构:
TOKYO METROPOLITAN INST MED SCI, BUNKYO KU, TOKYO 113, JAPAN TOKYO METROPOLITAN INST MED SCI, BUNKYO KU, TOKYO 113, JAPAN

Goldberg, AL
论文数: 0 引用数: 0
h-index: 0
机构:
TOKYO METROPOLITAN INST MED SCI, BUNKYO KU, TOKYO 113, JAPAN TOKYO METROPOLITAN INST MED SCI, BUNKYO KU, TOKYO 113, JAPAN
[6]
Proteasome subunit Rpn1 binds ubiquitin-like protein domains
[J].
Elsasser, S
;
Gali, RR
;
Schwickart, M
;
Larsen, CN
;
Leggett, DS
;
Müller, B
;
Feng, MT
;
Tübing, F
;
Dittmar, GAG
;
Finley, D
.
NATURE CELL BIOLOGY,
2002, 4 (09)
:725-730

论文数: 引用数:
h-index:
机构:

Gali, RR
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Schwickart, M
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Larsen, CN
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Leggett, DS
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Müller, B
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Feng, MT
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Tübing, F
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Dittmar, GAG
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Finley, D
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[7]
INHIBITION OF PROTEASOME ACTIVITIES AND SUBUNIT-SPECIFIC AMINO-TERMINAL THREONINE MODIFICATION BY LACTACYSTIN
[J].
FENTEANY, G
;
STANDAERT, RF
;
LANE, WS
;
CHOI, S
;
COREY, EJ
;
SCHREIBER, SL
.
SCIENCE,
1995, 268 (5211)
:726-731

论文数: 引用数:
h-index:
机构:

STANDAERT, RF
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, HOWARD HUGHES MED INST, DEPT CHEM, CAMBRIDGE, MA 02138 USA

LANE, WS
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, HOWARD HUGHES MED INST, DEPT CHEM, CAMBRIDGE, MA 02138 USA

CHOI, S
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, HOWARD HUGHES MED INST, DEPT CHEM, CAMBRIDGE, MA 02138 USA

COREY, EJ
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, HOWARD HUGHES MED INST, DEPT CHEM, CAMBRIDGE, MA 02138 USA

SCHREIBER, SL
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, HOWARD HUGHES MED INST, DEPT CHEM, CAMBRIDGE, MA 02138 USA
[8]
The regulatory particle of the Saccharomyces cerevisiae proteasome
[J].
Glickman, MH
;
Rubin, DM
;
Fried, VA
;
Finley, D
.
MOLECULAR AND CELLULAR BIOLOGY,
1998, 18 (06)
:3149-3162

Glickman, MH
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Rubin, DM
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Fried, VA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Finley, D
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[9]
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3
[J].
Glickman, MH
;
Rubin, DM
;
Coux, O
;
Wefes, I
;
Pfeifer, G
;
Cjeka, Z
;
Baumeister, W
;
Fried, VA
;
Finley, D
.
CELL,
1998, 94 (05)
:615-623

Glickman, MH
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Rubin, DM
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Coux, O
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Wefes, I
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Pfeifer, G
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Cjeka, Z
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Baumeister, W
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Fried, VA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Finley, D
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[10]
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
[J].
Glickman, MH
;
Ciechanover, A
.
PHYSIOLOGICAL REVIEWS,
2002, 82 (02)
:373-428

Glickman, MH
论文数: 0 引用数: 0
h-index: 0
机构:
Technion Israel Inst Technol, Fac Biol, IL-32000 Haifa, Israel Technion Israel Inst Technol, Fac Biol, IL-32000 Haifa, Israel

Ciechanover, A
论文数: 0 引用数: 0
h-index: 0
机构: Technion Israel Inst Technol, Fac Biol, IL-32000 Haifa, Israel