Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity

被引：901

作者：

Pang, PT

Teng, HK

Zaitsev, E

Woo, NT

Sakata, K

Zhen, SH

Teng, KK

Yung, WH

Hempstead, BL

Lu, B ^{[1
]}

机构：

[1] NICHD, Sect Neural Dev & Plast, Lab Cellular & Synapt Neurophysiol, Bethesda, MD 20892 USA

[2] Cornell Univ, Weill Med Coll, Dept Med, Div Hematol, New York, NY 10021 USA

[3] Chinese Univ Hong Kong, Fac Med, Dept Physiol, Shatin, Hong Kong, Peoples R China

来源：

SCIENCE | 2004年 / 306卷 / 5695期

关键词：

D O I：

10.1126/science.1100135

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase tong-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus. Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression.

引用

页码：487 / 491

页数：5