Alterations of DNA methylation in hematologic malignancies

被引：40

作者：

Rush, LJ ^{[1
]}

Plass, C

机构：

[1] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA

[2] Ohio State Univ, Div Human Canc Genet, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Mol Virol, Columbus, OH 43210 USA

来源：

CANCER LETTERS | 2002年 / 185卷 / 01期

关键词：

DNA methylation; DNA hypomethylation; epigenetics; leukemia; hematologic malignancy; CpG island; demethylation; chemotherapeutics; acute myeloid leukemia; myelodysplastic syndrome; chronic lymphocytic leukemia; p15; p16;

D O I：

10.1016/S0304-3835(02)00288-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The DNA methylation profile of cancer cells is frequently characterized by global hypomethylation and simultaneous hypermethylation of selected CpG island gene promoters. In recent years, the epigenetic phenomenon of DNA promoter methylation has gained increasing recognition as an important mechanism for transcriptional inactivation of cancer related genes. Studies on both liquid and solid tumors have revealed myriad aberrant methylation events, some of which may provide important clues to the pathogenesis of these tumors. The identification of these methylation alterations and elucidation of the,mechanistic events surrounding them are of prime importance, as the methylation status of cancer cells can now be manipulated in vivo with demethylating chemotherapeutics. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 12

页数：12

共 103 条

[1]

Aggerholm A, 1999, CANCER RES, V59, P436

[2]

Ahuja N, 1998, CANCER RES, V58, P5489

[3] DNA methylation and chromatin structure regulate PU.1 expression [J].

Amaravadi, L ;

Klemsz, MJ .

DNA AND CELL BIOLOGY, 1999, 18 (12) :875-884

[4] ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia [J].

Asimakopoulos, FA ;

Shteper, PJ ;

Krichevsky, S ;

Fibach, E ;

Polliack, A ;

Rachmilewitz, E ;

Ben-Neriah, Y ;

Ben-Yehuda, D .

BLOOD, 1999, 94 (07) :2452-2460

[5] T cell differentiation: a mechanistic view [J].

Avni, O ;

Rao, A .

CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (06) :654-659

[6] Frequent methylation silencing of p15INK4b (MTS2) and p16INK4a (MTS1) in B-cell and T-cell lymphomas [J].

Baur, AS ;

Shaw, P ;

Burri, N ;

Delacrétaz, F ;

Bosman, FT ;

Chaubert, P .

BLOOD, 1999, 94 (05) :1773-1781

[7] DNA hypermethylation in tumorigenesis - epigenetics joins genetics [J].

Baylin, SB ;

Herman, JG .

TRENDS IN GENETICS, 2000, 16 (04) :168-174

[8] CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia [J].

Bechter, OE ;

Eisterer, W ;

Dlaska, M ;

Kühr, T ;

Thaler, J .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :26-33

[9] CPG-RICH ISLANDS AND THE FUNCTION OF DNA METHYLATION [J].

BIRD, AP .

NATURE, 1986, 321 (6067) :209-213

[10] p15INK4B CPG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing [J].

Cameron, EE ;

Baylin, SB ;

Herman, JG .

BLOOD, 1999, 94 (07) :2445-2451

← 1 2 3 4 5 6 7 8 9 10 →