To sialylate, or not to sialylate: that is the question

被引：196

作者：

Vimr, E ^{[1
]}

Lichtensteiger, C ^{[1
]}

机构：

[1] Univ Illinois, Dept Pathobiol, Div Microbiol & Immunol, Urbana, IL 61802 USA

来源：

TRENDS IN MICROBIOLOGY | 2002年 / 10卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0966-842X(02)02361-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most oropharyngeal pathogens express sialic acid units on their surfaces, mimicking the sialyl-rich mucin layer coating epithelial cells and the glycoconjugates present on virtually all host cell surfaces and serum proteins. Unlike the host's cells, which synthesize sialic acids endogenously, several microbial pathogens use truncated sialylation pathways. How microorganisms regulate sialic acid metabolism to ensure an adequate supply of free sugar for surface remodeling is a new area of research interest to basic scientists and those focused on the clinical outcome of the host-pathogen interaction.

引用

页码：254 / 257

页数：4