Monocyte and macrophage subsets along the continuum to heart failure: Misguided heroes or targetable villains?

被引：50

作者：

Glezeva, Nadezhda ^{[1
]}

Horgan, Stephen ^{[1
,2
]}

Baugh, John A. ^{[1
]}

机构：

[1] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Sch Med, Dublin 4, Ireland

[2] St Vincents Univ Hosp Healthcare Grp, Heart Failure Unit, Dublin, Ireland

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2015年 / 89卷

关键词：

Monocytes; Macrophages; Subsets; Inflammation; Cardiovascular disease; Heart failure; ACUTE MYOCARDIAL-INFARCTION; PRESERVED EJECTION FRACTION; CORONARY-ARTERY-DISEASE; DIASTOLIC DYSFUNCTION; CHEMOATTRACTANT PROTEIN-1; HYPERTENSIVE-RATS; MONONUCLEAR PHAGOCYTES; CARDIAC DYSFUNCTION; INFLAMMATORY CELLS; FIBROSIS;

D O I：

10.1016/j.yjmcc.2015.10.029

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The important contribution of monocytes and macrophages to cardiovascular disease and heart failure pathophysiology has attracted significant attention in the past several years. Moreover, subsets of these cells have been shown to partake in the initiation and exacerbation of several cardiovascular pathologies including atherosclerosis, myocardial infarction, pressure overload, cardiac ischemia and fibrosis. This review focuses on the role of monocytes and macrophages along the continuum to heart failure and the contribution of different cell subsets in promoting or inhibiting cardiac injury or repair. It outlines a primary role for the monocyte/macrophage system as an important regulator of cardiac inflammation and extracellular matrix remodelling in early and late stage heart disease with particular focus on phenotypic plasticity and the inflammatory and fibrotic functions of these cells. It also summarizes evidence from pre-clinical and clinical studies evaluating monocyte type regulation and its functional significance for development of cardiovascular disease and heart failure. Finally, current and prospective therapeutic approaches based on monocyte and macrophage manipulation for the treatment of cardiovascular disease and heart failure are discussed. Based on these data, future work in this fertile research area may aid in identifying potential diagnostic biomarkers and novel therapies for chronic heart failure. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：136 / 145

页数：10

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