Demonstrating the case that AD is a vascular disease: epidemiologic evidence

被引:209
作者
Launer, LJ [1 ]
机构
[1] NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Neuroepidemiol Sect, Bethesda, MD 20892 USA
关键词
Alzheimer's disease; vascular disease; epidemiology; risk factors;
D O I
10.1016/S0047-6374(01)00364-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要
Alzheimer's disease (AD) is the most frequent type of dementia in old age. The pathology of AD is not well understood. One hypothesis states that AD has a vascular basis. This hypothesis is controversial because AD has traditionally been studied and treated as a separate disease from vascular dementia. This article reviews the epidemiologic evidence supporting an association between AD and two major vascular risk factors-blood pressure and diabetes. Both methodologic and biologic explanations for these associations are discussed. Published by Elsevier Science Ireland Ltd.
引用
收藏
页码:61 / 77
页数:17
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