Demonstrating the case that AD is a vascular disease: epidemiologic evidence

被引：209

作者：

Launer, LJ ^{[1
]}

机构：

[1] NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Neuroepidemiol Sect, Bethesda, MD 20892 USA

来源：

AGEING RESEARCH REVIEWS | 2002年 / 1卷 / 01期

关键词：

Alzheimer's disease; vascular disease; epidemiology; risk factors;

D O I：

10.1016/S0047-6374(01)00364-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Alzheimer's disease (AD) is the most frequent type of dementia in old age. The pathology of AD is not well understood. One hypothesis states that AD has a vascular basis. This hypothesis is controversial because AD has traditionally been studied and treated as a separate disease from vascular dementia. This article reviews the epidemiologic evidence supporting an association between AD and two major vascular risk factors-blood pressure and diabetes. Both methodologic and biologic explanations for these associations are discussed. Published by Elsevier Science Ireland Ltd.

引用

收藏

页码：61 / 77

页数：17

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