A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia

被引：27

作者：

Takano, Ryo ^{[2
]}

Nidom, Chairul A. ^{[3
,4
]}

Kiso, Maki ^{[2
]}

Muramoto, Yukiko ^{[2
]}

Yamada, Shinya ^{[2
]}

Shinya, Kyoko ^{[5
]}

Sakai-Tagawa, Yuko ^{[2
]}

Kawaoka, Yoshihiro ^{[1
,2
,5
,6
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Minato Ku, Tokyo 1088639, Japan

[2] Univ Tokyo, Dept Microbiol & Immunol, Div Virol, Minato Ku, Tokyo 1088639, Japan

[3] Airlangga Univ, Fac Vet Med, Surabaya 60115, Indonesia

[4] Airlangga Univ, Trop Dis Ctr, Collaborating Res Ctr Emerging & Reemerging Infec, Surabaya 60115, Indonesia

[5] Kobe Univ, Grad Sch Med, Int Ctr Med Res & Treatment, Chuo Ku, Kobe, Hyogo 6500017, Japan

[6] Univ Wisconsin, Sch Vet Med, Dept Pathol Sci, Madison, WI 53706 USA

来源：

ARCHIVES OF VIROLOGY | 2009年 / 154卷 / 04期

基金：

日本科学技术振兴机构;

关键词：

A VIRUSES; AMINO-ACID; HONG-KONG; PIGS; TRANSMISSION; SPECIFICITY; INFECTION; OUTBREAK; GENE; H3N2;

D O I：

10.1007/s00705-009-0353-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Highly pathogenic avian influenza H5N1 viruses are circulating in many countries. We recently discovered that these viruses have been transmitted to pigs on multiple occasions in Indonesia. To investigate whether avian H5N1 influenza viruses adapted to mammals through their introduction into pigs, we examined the growth of avian and swine isolates in cell culture and compared their pathogenicity in mice. We found that swine isolates were less virulent to mice than avian isolates, suggesting that the viruses became attenuated during their replication in pigs. Continuous surveillance of H5N1 viruses among pigs is clearly warranted.

引用

页码：677 / 681

页数：5

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