A small-systems approach to motor pattern generation

被引:255
作者
Nusbaum, MP [1 ]
Beenhakker, MP [1 ]
机构
[1] Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA
关键词
D O I
10.1038/417343a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
How neuronal networks enable animals, humans included, to make coordinated movements is a continuing goal of neuroscience research. The stomatogastric nervous system of decapod crustaceans, which contains a set of distinct but interacting motor circuits, has contributed significantly to the general principles guiding our present understanding of how rhythmic motor circuits operate at the cellular level. This results from a detailed documentation of the circuit dynamics underlying motor pattern generation in this system as well as its modulation by individual transmitters and neurons.
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收藏
页码:343 / 350
页数:8
相关论文
共 100 条
[11]  
Combes D, 1999, J NEUROSCI, V19, P3620
[12]   NEUROPEPTIDE FUSION OF 2 MOTOR-PATTERN GENERATOR CIRCUITS [J].
DICKINSON, PS ;
MECSAS, C ;
MARDER, E .
NATURE, 1990, 344 (6262) :155-158
[13]   Step, swim, and scratch motor patterns in the turtle [J].
Earhart, GM ;
Stein, PSG .
JOURNAL OF NEUROPHYSIOLOGY, 2000, 84 (05) :2181-2190
[14]   Neuronal coincidence detection by voltage-sensitive electrical synapses [J].
Edwards, DH ;
Yeh, SR ;
Krasne, FB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :7145-7150
[15]   MECHANISMS OF GASTRIC RHYTHM GENERATION IN THE ISOLATED STOMATOGASTRIC GANGLION OF SPINY LOBSTERS - BURSTING PACEMAKER POTENTIALS, SYNAPTIC-INTERACTIONS, AND MUSCARINIC MODULATION [J].
ELSON, RC ;
SELVERSTON, AI .
JOURNAL OF NEUROPHYSIOLOGY, 1992, 68 (03) :890-907
[16]   Dynamic control of irregular bursting in an identified neuron of an oscillatory circuit [J].
Elson, RC ;
Huerta, R ;
Abarbanel, HDI ;
Rabinovich, MI ;
Selverston, AI .
JOURNAL OF NEUROPHYSIOLOGY, 1999, 82 (01) :115-122
[17]   Electrical synapses between GABA-releasing interneurons [J].
Galarreta, M ;
Hestrin, S .
NATURE REVIEWS NEUROSCIENCE, 2001, 2 (06) :425-433
[18]   Global structure, robustness, and modulation of neuronal models [J].
Goldman, MS ;
Golowasch, J ;
Marder, E ;
Abbott, LF .
JOURNAL OF NEUROSCIENCE, 2001, 21 (14) :5229-5238
[19]   FULL-WAVE RECTIFICATION FROM A MIXED ELECTRICAL-CHEMICAL SYNAPSE [J].
GRAUBARD, K ;
HARTLINE, DK .
SCIENCE, 1987, 237 (4814) :535-537
[20]   GABA enhances transmission at an excitatory glutamatergic synapse [J].
Gutovitz, S ;
Birmingham, JT ;
Luther, JA ;
Simon, DJ ;
Marder, E .
JOURNAL OF NEUROSCIENCE, 2001, 21 (16) :5935-5943