Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis

被引：314

作者：

Oh, Dong-Chan ^{[2
]}

Poulsen, Michael ^{[1
]}

Currie, Cameron R. ^{[1
]}

Clardy, Jon ^{[2
]}

机构：

[1] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

ABSOLUTE-CONFIGURATION; MICROBE SYMBIOSIS; GROWING ANTS; AMINO-ACIDS; STREPTOMYCES; DERIVATIVES; PEPTIDE;

D O I：

10.1038/nchembio.159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fungus-growing ants engage in mutualistic associations with both the fungus they cultivate for food and actinobacteria (Pseudonocardia spp.) that produce selective antibiotics to defend that fungus from specialized fungal parasites. We have analyzed one such system at the molecular level and found that the bacterium associated with the ant Apterostigma dentigerum produces dentigerumycin, a cyclic depsipeptide with highly modified amino acids, to selectively inhibit the associated parasitic fungus (Escovopsis sp.).

引用

页码：391 / 393

页数：3

共 20 条

[1] Bioactive microbial metabolites -: A personal view [J].

Bérdy, J .

JOURNAL OF ANTIBIOTICS, 2005, 58 (01) :1-26

[2] Coevolved crypts and exocrine glands support mutualistic bacteria in fungus-growing ants [J].

Currie, CR ;

Poulsen, M ;

Mendenhall, J ;

Boomsma, JJ ;

Billen, J .

SCIENCE, 2006, 311 (5757) :81-83

[3] Fungus-growing ants use antibiotic-producing bacteria to control garden parasites [J].

Currie, CR ;

Scott, JA ;

Summerbell, RC ;

Malloch, D .

NATURE, 1999, 398 (6729) :701-704

[4] Ancient tripartite coevolution in the attine ant-microbe symbiosis [J].

Currie, CR ;

Wong, B ;

Stuart, AE ;

Schultz, TR ;

Rehner, SA ;

Mueller, UG ;

Sung, GH ;

Spatafora, JW ;

Straus, NA .

SCIENCE, 2003, 299 (5605) :386-388

[5] The evolution of gene collectives: How natural selection drives chemical innovation [J].

Fischbach, Michael A. ;

Walsh, Christopher T. ;

Clardy, Jon .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (12) :4601-4608

[6] Simultaneous detection and determination of the absolute configuration of thiazole-containing amino acids in a peptide [J].

Fujii, K ;

Yahashi, Y ;

Nakano, T ;

Imanishi, S ;

Baldia, SF ;

Harada, K .

TETRAHEDRON, 2002, 58 (34) :6873-6879

[7] A nonempirical method using LC/MS for determination of the absolute configuration of constituent amino acids in a peptide: Combination of Marfey's method with mass spectrometry and its practical application [J].

Fujii, K ;

Ikai, Y ;

Oka, H ;

Suzuki, M ;

Harada, K .

ANALYTICAL CHEMISTRY, 1997, 69 (24) :5146-5151

[8]

GRAFE U, 1995, J ANTIBIOT, V48, P119

[9] Symbiotic bacteria protect wasp larvae from fungal infestation [J].

Kaltenpoth, M ;

Göttler, W ;

Herzner, G ;

Strohm, E .

CURRENT BIOLOGY, 2005, 15 (05) :475-479

[10] Stereochemical determination of acyclic structures based on carbon-proton spin-coupling constants. A method of configuration analysis for natural products [J].

Matsumori, N ;

Kaneno, D ;

Murata, M ;

Nakamura, H ;

Tachibana, K .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (03) :866-876

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