Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

被引：258

作者：

Talon, J

Salvatore, M

O'Neill, RE

Nakaya, Y

Zheng, HY

Muster, T

Garcia-Sastre, A

Palese, P

机构：

[1] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

[2] Univ Vienna, Sch Med, Dept Dermatol, A-1090 Vienna, Austria

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 08期

关键词：

D O I：

10.1073/pnas.070525997

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral NS1 proteins are highly attenuated in the mouse host, yet provide protection from challenge with wild-type viruses.

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页码：4309 / 4314

页数：6

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