The Anti-Cancer Activity of Noscapine: A Review

被引:123
作者
Mahmoudian, Massoud [1 ]
Rahimi-Moghaddam, Parvaneh [1 ]
机构
[1] Iran Univ Med Sci, Coll Med, Dept Pharmacol, Razi Inst Drug Res, Tehran, Iran
关键词
Noscapine; antitussive; anti-cancer; anti-mitotic; apoptosis; GUINEA-PIG BRAIN; DEXTROMETHORPHAN BINDING-SITES; OVARIAN-CANCER CELLS; PERTURB MITOSIS; BREAST-CANCER; H-3; NOSCAPINE; APOPTOSIS; PHARMACOKINETICS; TOXICITY; ANALOGS;
D O I
10.2174/157489209787002524
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent. This drug can be used orally. When the resistance to other anti-cancer drugs such as paclitaxel menifests, noscapine might be effective. Therefore, noscapine and its analogs have great potential as novel anticancer agents.
引用
收藏
页码:92 / 97
页数:6
相关论文
共 49 条
[21]   DETERMINATION OF NOSCAPINE AND ITS METABOLITES IN PLASMA BY COUPLED-COLUMN LIQUID-CHROMATOGRAPHY [J].
JOHANSSON, M ;
ALM, AT ;
FORSMOBRUCE, H ;
JACOBSSON, S ;
WESTERLUND, D .
JOURNAL OF CHROMATOGRAPHY, 1988, 459 :301-311
[22]   Noscapine and analogues as potential chemotherapeutic agents [J].
Joshi, HC ;
Zhou, J .
DRUG NEWS & PERSPECTIVES, 2000, 13 (09) :543-546
[23]  
KAPP J, 2006, Patent No. 20067090853
[24]   PHARMACOKINETICS OF ORAL NOSCAPINE [J].
KARLSSON, MO ;
DAHLSTROM, B ;
ECKERNAS, SA ;
JOHANSSON, M ;
ALM, AT .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1990, 39 (03) :275-279
[25]   ESTIMATION OF BINDING PARAMETERS BY KINETIC DATA-ANALYSIS - DIFFERENTIATION BETWEEN ONE AND 2 BINDING-SITES [J].
KARLSSON, MO ;
NEIL, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 148 (01) :115-121
[26]   CHARACTERIZATION OF HIGH-AFFINITY BINDING-SITES FOR THE ANTITUSSIVE [H-3] NOSCAPINE IN GUINEA-PIG BRAIN-TISSUE [J].
KARLSSON, MO ;
DAHLSTROM, B ;
NEIL, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 145 (02) :195-203
[27]   Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to Taxol [J].
Kavallaris, M ;
Burkhart, CA ;
Horwitz, SB .
BRITISH JOURNAL OF CANCER, 1999, 80 (07) :1020-1025
[28]   Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses [J].
Ke, Y ;
Ye, K ;
Grossniklaus, HE ;
Archer, DR ;
Joshi, HC ;
Kapp, JA .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2000, 49 (4-5) :217-225
[29]  
KIM TS, 2006, Patent No. 2006060318
[30]   Yeast DEL assay detects clastogens [J].
Kirpnick, Z ;
Homiski, M ;
Rubitski, E ;
Repnevskaya, M ;
Howlett, N ;
Aubrecht, J ;
Schiestl, RH .
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2005, 582 (1-2) :116-134