LTP and LTD: An embarrassment of riches

被引：2857

作者：

Malenka, RC ^{[1
]}

Bear, MF

机构：

[1] Stanford Univ, Sch Med, Nancy Pritzker Lab, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA

[2] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[3] MIT, Picower Ctr Learning & Memory, Cambridge, MA 02139 USA

来源：

NEURON | 2004年 / 44卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2004.09.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission, are widespread phenomena expressed at possibly every excitatory synapse in the mammalian brain. It is now clear that "LTP" and "LTD" are not unitary phenomena. Their mechanisms vary depending on the synapses and circuits in which they operate. Here we review those forms of LTP and LTD for which mechanisms have been most firmly established. Examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function.

引用

页码：5 / 21

页数：17

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