Identification of a bovine coronavirus packaging signal

被引：35

作者：

Cologna, R

Hogue, BG

机构：

[1] Baylor Coll Med, Dept Microbiol & Immunol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol Virol, Houston, TX 77030 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 01期

关键词：

D O I：

10.1128/JVI.74.1.580-583.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A region of the bovine coronavirus (BCV) genome that functions as a packaging signal has been cloned,The 291-nucleotide clone shares 72% homology with the region of mouse hepatitis coronavirus (MHV) gene Ib that contains the packaging signal. RNA transcripts were packaged into both BCV and MHV virions when the cloned region was appended to a noncoronavinrs RNA. This is the first identification of a BCV packaging signal. The data demonstrate that the BCV genome contains a sequence that is conserved at both the sequence and functional levels, thus broadening our insight into coronavirus packaging.

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页码：580 / 583

页数：4

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