Immunity, Inflammation, and Vaccines for Helicobacter pylori

被引：43

作者：

D'Elios, Mario M. ^{[1
]}

Czinn, Steven J. ^{[2
]}

机构：

[1] Univ Florence, Dept Expt & Clin Med, I-50134 Florence, Italy

[2] Univ Maryland, Sch Med, Dept Pediat, Baltimore, MD 21201 USA

来源：

HELICOBACTER | 2014年 / 19卷

关键词：

DENDRITIC CELLS; DOWN-REGULATION; BACTERIAL CAGA; INFECTION; RESPONSES; VACCINATION; ACTIVATION; CYTOKINE; POLYMORPHISMS; ASSOCIATION;

D O I：

10.1111/hel.12156

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Helicobacter pylori colonizes mucosa, activates Toll-like and Nod-like receptors, and usually elicits a gastric T-helper 1/17 (Th1/Th17) type of immune response. Among several bacterial factors, the secreted peptidyl prolyl cis, trans-isomerase of H. pylori represents a key factor driving Th17 inflammation. A complex and fascinating balance between H. pylon and host factors takes part in the gastric niche and is responsible for the chronicity of the infection. Novel insights into the innate and adaptive responses against H. pylori, dealing wilt gastric epithelial cells, cytokines, and immune evasion have been elucidated over the past year and are discussed for the development. of an effective vaccine.

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页码：19 / 26

页数：8

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