CD27(+) CD56Bright natural killer cells may be involved in spontaneous clearance of acute hepatitis C in HIV-positive patients

被引：6

作者：

Eisenhardt, Marianne ^{[1
]}

Glaessner, Andreas ^{[1
]}

Wolter, Franziska ^{[1
]}

Kraemer, Benjamin ^{[1
]}

Kokordelis, Pavlos ^{[1
]}

Nischalke, Hans-Dieter ^{[1
]}

Boesecke, Christoph ^{[1
]}

Rockstroh, Juergen K. ^{[1
]}

Spengler, Ulrich ^{[1
]}

Nattermann, Jacob ^{[1
]}

机构：

[1] Univ Bonn, Dept Internal Med 1, German Ctr Infect Res DZIF, D-53105 Bonn, Germany

来源：

AIDS | 2014年 / 28卷 / 13期

关键词：

acute hepatitis C; CD27; HIV/hepatitis C virus coinfection; intereron-gamma; natural killer cells; VIRUS-REPLICATION; MEDIATED INHIBITION; T-CELL; SUBSETS; DEFINES;

D O I：

10.1097/QAD.0000000000000355

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: The objective of this study was to analyse the potential role of CD27 in natural killer (NK) cell-mediated control of hepatitis C virus (HCV) infection in HIV-positive patients. Design: Frequency of CD27-expressing CD56(Bright) NK cells was analysed in HIV mono-infected individuals and HIV-positive patients with acute or chronic hepatitis C. Anti-HCV activity of CD27(+) and CD27(-) NK cells was compared. Methods: NK cell mediated inhibition of HCV replication was analysed using the HUH7 HCV Replicon model. NK cell phenotype and interferon (IFN) secretion was studied by flowcytometry. Results: High frequency of CD27(+) CD56(Bright) NK cells is associated with spontaneous clearance of acute hepatitis C in HIV-positive patients. Accordingly, we found CD27(+)CD56(Bright) NK cells to display strong anti-HCV activity. Conclusion: Our results underline the important role of NK cells in modulating outcome of HCV infection. (C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

引用

页码：1879 / 1884

页数：6

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