Zn2+-dependent peptide nucleic acids probes

被引:31
作者
Mokhir, A [1 ]
Krämer, R [1 ]
Wolf, H [1 ]
机构
[1] Heidelberg Univ, D-69120 Heidelberg, Germany
关键词
D O I
10.1021/ja0397613
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Binding of bis-picolylamine-naphthalene diimide-peptide nucleic acid conjugates to complementary DNA is strongly dependent upon Zn2+; ultimately, hybridization is switched ON in the presence μM Zn2+. Copyright © 2003 American Chemical Society.
引用
收藏
页码:6208 / 6209
页数:2
相关论文
共 19 条
[1]   Synthesis and characterization of a peptide nucleic acid conjugated to a D-peptide analog of insulin-like growth factor 1 for increased cellular uptake [J].
Basu, S ;
Wickstrom, E .
BIOCONJUGATE CHEMISTRY, 1997, 8 (04) :481-488
[2]   Steroid-DNA interactions increasing stability, sequence-selectivity, DNA/RNA discrimination, and hypochromicity of oligonucleotide duplexes [J].
Bleczinski, CF ;
Richert, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (47) :10889-10894
[3]  
Boffa LC, 2000, CANCER RES, V60, P2258
[4]   Zinc metabolism in the brain: Relevance to human neurodegenerative disorders [J].
Cuajungco, MP ;
Lees, GJ .
NEUROBIOLOGY OF DISEASE, 1997, 4 (3-4) :137-169
[5]  
FREDERICKSON CJ, 1989, INT REV NEUROBIOL, V31, P145
[6]  
FREDERICKSON CJ, 2000, J NUTR, V42, P877
[7]   METALLOREGULATION IN THE SEQUENCE SPECIFIC BINDING OF SYNTHETIC MOLECULES TO DNA [J].
GRIFFIN, JH ;
DERVAN, PB .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (22) :6840-6842
[8]   Enhanced cooperative binding of oligonucleotides to form DNA duplexes mediated by metal ion chelation [J].
Horsey, I ;
Krishnan-Ghosh, Y ;
Balasubramanian, S .
CHEMICAL COMMUNICATIONS, 2002, (17) :1950-1951
[9]   Metal ion-directed cooperative triple helix formation of glutamic acid-oligonucleotide conjugate [J].
Ihara, T ;
Takeda, Y ;
Jyo, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (08) :1772-1773
[10]   Cellular delivery of peptide nucleic acid (PNA) [J].
Koppelhus, U ;
Nielsen, PE .
ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (02) :267-280