Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis

被引：73

作者：

Chen, Yanke ^{[1
,2
,3
]}

Zhang, Hongxin ^{[4
]}

Gou, Xingchun ^{[1
,2
,3
]}

Horikawa, Yohei ^{[5
]}

Xing, Jinliang ^{[1
,2
,3
]}

Chen, Zhinan ^{[1
,2
,3
]}

机构：

[1] Fourth Mil Med Univ, Dept Cell Biol, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Cell Engn Res Ctr, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Peoples R China

[4] Fourth Mil Med Univ, Tangdu Hosp, Dept Intervent Radiol, Xian 710038, Peoples R China

[5] Akita Univ, Sch Med, Dept Urol, Akita 010, Japan

来源：

CANCER LETTERS | 2009年 / 278卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Angiogenesis; HAb18G/CD147; Human umbilical vein endothelial cells; MATRIX-METALLOPROTEINASE INDUCER; COLLAGENASE-STIMULATORY FACTOR; BRAIN-BARRIER FUNCTION; HEPATOCELLULAR-CARCINOMA; EMMPRIN EXPRESSION; GROWTH-FACTOR; CD147; TUMOR; MEMBER; INVASION;

D O I：

10.1016/j.canlet.2009.01.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells has yet to be established. In this study, we found that the expression of HAb18G/CD147 was significantly upregulated in activated HUVECs. The inhibition of HAb18G/CD147 expression by specific siRNA led to significantly decreased angiogenesis in vitro. Our data indicate that HAb18G/CD147 may regulate angiogenesis via several mechanisms including proliferation, survival, migration, MMPs secretion, and PI3K/Akt activation. Our findings for the first time suggest that upregulation of HAb18G/CD147 in activated HUVECs might play an important role in angiogenesis. (c) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：113 / 121

页数：9

共 49 条

[1]

CORRELATION OF BLOOD-BRAIN-BARRIER FUNCTION AND HT7 PROTEIN DISTRIBUTION IN CHICK BRAIN CIRCUMVENTRICULAR ORGANS [J].

ALBRECHT, U ;

SEULBERGER, H ;

SCHWARZ, H ;

RISAU, W .

BRAIN RESEARCH, 1990, 535 (01) :49-61

[2]

Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism [J].

Baba, Miyako ;

Inoue, Masahiro ;

Itoh, Kazuyuki ;

Nishizawa, Yasuko .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 374 (01) :111-116

[3]

BISWAS C, 1995, CANCER RES, V55, P434

[4]

ENDOTHELIAL-CELL COMPATIBILITY TESTING OF 3 DIFFERENT PELLETHANES [J].

BORDENAVE, L ;

BAQUEY, C ;

BAREILLE, R ;

LEFEBVRE, F ;

LAUROUA, C ;

GUERIN, V ;

ROUAIS, F ;

MORE, N ;

VERGNES, C ;

ANDERSON, JM .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1993, 27 (11) :1367-1381

[5]

EMMPRIN-mediated MMP regulation in tumor and endothelial cells [J].

Caudroy, S ;

Polette, M ;

Nawrocki-Raby, B ;

Cao, J ;

Toole, BP ;

Zucker, S ;

Birembaut, P .

CLINICAL & EXPERIMENTAL METASTASIS, 2002, 19 (08) :697-702

[6]

Expression of the extracellular matrix metalloproteinase inducer (EMMPRIN) and the matrix metalloproteinase-2 in bronchopulmonary and breast lesions [J].

Caudroy, S ;

Polette, M ;

Tournier, JM ;

Burlet, H ;

Toole, B ;

Zucker, S ;

Birembaut, P .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1999, 47 (12) :1575-1580

[7]

Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinases during mouse embryonic development [J].

Chen, Li ;

Nakai, Masaaki ;

Belton, Robert J., Jr. ;

Nowak, Romana A. .

REPRODUCTION, 2007, 133 (02) :405-414

[8]

Chen XueShen Chen XueShen, 2008, China Fruits, P1

[9]

Chen ZN, 1999, J CELL MOL IMMUNOL, V15, P34

[10]

ORGANIZATION OF THE MOUSE GP42/BASIGIN GENE - A MEMBER OF THE IG SUPERFAMILY [J].

CHENG, Y ;

LI, XB ;

KAMHOLZ, J ;

BURNS, FR .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1994, 1217 (03) :307-311

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