Hope versus hype: what can additive manufacturing realistically offer trauma and orthopedic surgery?

被引：35

作者：

Gibbs, David M. R. ^{[1
]}

Vaezi, Mohammad ^{[2
]}

Yang, Shoufeng ^{[2
]}

Oreffo, Richard O. C. ^{[1
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, Inst Dev Sci MP887, Bone & Joint Res Grp,Ctr Human Dev Stem Cells & R, Southampton SO16 6YD, Hants, England

[2] Univ Southampton, Fac Engn & Environm, Southampton SO17 1BJ, Hants, England

来源：

REGENERATIVE MEDICINE | 2014年 / 9卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

additive manufacturing; bone graft; orthopedic surgery; 3D printing; AUTOLOGOUS CHONDROCYTE IMPLANTATION; MESENCHYMAL STEM-CELLS; BONE-GRAFT SUBSTITUTES; HARD-TISSUE SCAFFOLDS; INTERBODY FUSION; MORPHOGENETIC PROTEIN-2; BIOLOGICAL PERFORMANCE; IN-VIVO; POLYCAPROLACTONE; DEPOSITION;

D O I：

10.2217/RME.14.20

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Additive manufacturing (AM) is a broad term encompassing 3D printing and several other varieties of material processing, which involve computer-directed layer-by-layer synthesis of materials. As the popularity of AM increases, so to do expectations of the medical therapies this process may offer. Clinical requirements and limitations of current treatment strategies in bone grafting, spinal arthrodesis, osteochondral injury and treatment of periprosthetic joint infection are discussed. The various approaches to AM are described, and the current state of clinical translation of AM across these orthopedic clinical scenarios is assessed. Finally, we attempt to distinguish between what AM may offer orthopedic surgery from the hype of what has been promised by AM.

引用

页码：535 / 549

页数：15

共 82 条

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Biological performance of a polycaprolactone-based scaffold used as fusion cage device in a large animal model of spinal reconstructive surgery [J].