Increased expression of cardiac phosphatases in patients with end-stage heart failure

被引：211

作者：

Neumann, J

Eschenhagen, T

Jones, LR

Linck, B

Schmitz, W

Scholz, H

Zimmermann, N

机构：

[1] UNIV HAMBURG, HOSP EPPENDORF, ABT ALLGEMEINE PHARMAKOL, D-20246 HAMBURG, GERMANY

[2] KRANNERT CARDIOVASC RES INST, INDIANAPOLIS, IN 46202 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1997年 / 29卷 / 01期

关键词：

phosphatases; human heart failure; protein phosphorylation;

D O I：

10.1006/jmcc.1996.0271

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure. (C) 1997 Academic Press Limited

引用

页码：265 / 272

页数：8

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