Increased expression of cardiac phosphatases in patients with end-stage heart failure

被引：211

作者：

Neumann, J

Eschenhagen, T

Jones, LR

Linck, B

Schmitz, W

Scholz, H

Zimmermann, N

机构：

[1] UNIV HAMBURG, HOSP EPPENDORF, ABT ALLGEMEINE PHARMAKOL, D-20246 HAMBURG, GERMANY

[2] KRANNERT CARDIOVASC RES INST, INDIANAPOLIS, IN 46202 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1997年 / 29卷 / 01期

关键词：

phosphatases; human heart failure; protein phosphorylation;

D O I：

10.1006/jmcc.1996.0271

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure. (C) 1997 Academic Press Limited

引用

页码：265 / 272

页数：8

共 32 条

[11] ABNORMAL INTRACELLULAR CALCIUM HANDLING IN MYOCARDIUM FROM PATIENTS WITH END-STAGE HEART-FAILURE
GWATHMEY, JK
COPELAS, L
MACKINNON, R
SCHOEN, FJ
FELDMAN, MD
GROSSMAN, W
MORGAN, JP
[J]. CIRCULATION RESEARCH, 1987, 61 (01) : 70 - 76
[12] MECHANISMS OF BETA-ADRENERGIC STIMULATION OF CARDIAC CA2+ CHANNELS REVEALED BY DISCRETE-TIME MARKOV ANALYSIS OF SLOW GATING
HERZIG, S
PATIL, P
NEUMANN, J
STASCHEN, CM
YUE, DT
[J]. BIOPHYSICAL JOURNAL, 1993, 65 (04) : 1599 - 1612
[13] STIMULATION OF PROTEIN PHOSPHATASES AS A MECHANISM OF THE MUSCARINIC-RECEPTOR-MEDIATED INHIBITION OF CARDIAC L-TYPE CA2+ CHANNELS
HERZIG, S
MEIER, A
PFEIFFER, M
NEUMANN, J
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1995, 429 (04): : 531 - 538
[14] PROTEIN-KINASES AND PHOSPHATASES - THE YIN AND YANG OF PROTEIN-PHOSPHORYLATION AND SIGNALING
HUNTER, T
[J]. CELL, 1995, 80 (02) : 225 - 236
[15] JONES LR, 1985, CURRENT TOPICS MEMBR, P11
[16] Linck B, 1996, CARDIOVASC RES, V31, P625
[17] Effects of cantharidin on force of contraction and phosphatase activity in nonfailing and failing human hearts
Linck, B
Boknik, P
Knapp, J
Muller, FU
Neumann, J
Schmitz, W
Vahlensieck, U
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1996, 119 (03) : 545 - 550
[18] TARGETED ABLATION OF THE PHOSPHOLAMBAN GENE IS ASSOCIATED WITH MARKEDLY ENHANCED MYOCARDIAL-CONTRACTILITY AND LOSS OF BETA-AGONIST STIMULATION
LUO, WS
GRUPP, IL
HARRER, J
PONNIAH, S
GRUPP, G
DUFFY, JJ
DOETSCHMAN, T
KRANIAS, EG
[J]. CIRCULATION RESEARCH, 1994, 75 (03) : 401 - 409
[19] IDENTIFICATION OF THE MAJOR PROTEIN PHOSPHATASES IN MAMMALIAN CARDIAC-MUSCLE WHICH DEPHOSPHORYLATE PHOSPHOLAMBAN
MACDOUGALL, LK
JONES, LR
COHEN, P
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 196 (03): : 725 - 734
[20] CA2+-TRANSPORTING ATPASE, PHOSPHOLAMBAN, AND CALSEQUESTRIN LEVELS IN NONFAILING AND FAILING HUMAN MYOCARDIUM
MOVSESIAN, MA
KARIMI, M
GREEN, K
JONES, LR
[J]. CIRCULATION, 1994, 90 (02) : 653 - 657

← 1 2 3 4 →