Enantioselective hydrogenation of 2-methyl-2-pentenoic acid over cinchonidine-modified Pd/alumina

被引：86

作者：

Borszeky, K ^{[1
]}

Mallat, T ^{[1
]}

Baiker, A ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,DEPT CHEM ENGN & IND CHEM,ETH ZENTRUM,CH-8092 ZURICH,SWITZERLAND

来源：

CATALYSIS LETTERS | 1996年 / 41卷 / 3-4期

关键词：

enantioselective; hydrogenation; cinchonidine; Pd/alumina; methylpentenoic acid;

D O I：

10.1007/BF00811491

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A chiral alkanoic acid was prepared with up to 52% excess of the (S) enantiomer by hydrogenating alpha,beta-unsaturated carboxylic acid with a cinchonidine-Pd/Al2O3 catalyst system. Favourable conditions are: high surface hydrogen concentration (greater than or equal to 60 bar hydrogen pressure, low catalyst concentration and apolar solvents), near ambient temperature and a cinchonidine/reactant molar ratio of at least 0.4 mol%. It is proposed that high hydrogen solubility and the presence of 2-methyl-2-pentenoic acid reactant as dimers are advantageous for enantiodifferentiation.

引用

页码：199 / 202

页数：4

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