Salivary gland P2 nucleotide receptors

被引:60
作者
Turner, JT [1 ]
Landon, LA
Gibbons, SJ
Talamo, BR
机构
[1] Univ Missouri, Sch Med, Dept Pharmacol, Columbia, MO 65212 USA
[2] Tufts Univ, Sch Med, Dept Neurosci, Boston, MA 02111 USA
[3] Tufts Univ, Sch Med, Dept Physiol, Boston, MA 02111 USA
关键词
extracellular nucleotides; P2X and P2Y receptors; signal transduction; salivary secretion; permeabilization;
D O I
10.1177/10454411990100020701
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The effects of ATP on salivary glands have been recognized since 1982. Functional and pharmacological studies of the P2 nucleotide receptors that mediate the effects of ATP and other extracellular nucleotides have been supported by the cloning of receptor cDNAs, by the expression of the receptor proteins, and by the identification in salivary gland cells of multiple P2 receptor subtypes. Currently, there is evidence obtained from pharmacological and molecular biology approaches for the expression in salivary gland of two P2X ligand-gated ion channels, P(2Z)/P2X(7) and P2X(4), and two P2Y G protein-coupled receptors, P2Y(1) and P2Y(2). Activation of each of these receptor subtypes increases intracellular Ca(2+), a second messenger with a key role in the regulation of salivary gland secretion. Through Ca(2+) regulation and other mechanisms, P2 receptors appear to regulate salivary cell volume, ion and protein secretion, and increased permeability to small molecules that may be involved in cytotoxicity. Some localization of the various salivary P2 receptor subtypes to specific cells and membrane subdomains has been reported, along with evidence for the co-expression of multiple P2 receptor subtypes within specific salivary acinar or duct cells. However, additional studies in vivo and with intact organ preparations are required to define clearly the roles the various P2 receptor subtypes play in salivary gland physiology and pathology. Opportunities for eventual utilization of these receptors as pharmacotherapeutic targets in diseases involving salivary gland dysfunction appear promising.
引用
收藏
页码:210 / 224
页数:15
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