Hydrogels for cardiac tissue engineering

被引：133

作者：

Camci-Unal, Gulden ^{[1
,2
]}

Annabi, Nasim ^{[1
,2
,3
]}

Dokmeci, Mehmet R. ^{[1
,2
,3
]}

Liao, Ronglih ^{[4
]}

Khademhosseini, Ali ^{[1
,2
,3
,5
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Biomed Engn,Dept Med, Cambridge, MA 02139 USA

[2] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Harvard Univ, Wyss Inst Biol Inspired Engn, Cambridge, MA 02139 USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Cardiovasc Div,Dept Med,Cardiac Muscle Res Lab, Cambridge, MA 02139 USA

[5] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 980, Japan

来源：

NPG ASIA MATERIALS | 2014年 / 6卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

biomaterials; cardiac tissue engineering; hydrogels; regenerative medicine; stem cells; MESENCHYMAL STEM-CELLS; ENDOTHELIAL GROWTH-FACTOR; IN-VIVO; CARDIOMYOGENIC DIFFERENTIATION; ELECTRICAL-STIMULATION; INJECTABLE HYDROGELS; HYBRID HYDROGELS; FACTOR DELIVERY; CAPILLARY-FLOW; MYOCARDIUM;

D O I：

10.1038/am.2014.19

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Cardiac failure is a critical condition that results in life-threatening consequences. Due to a limited number of organ donors, tissue engineering has emerged to generate functional tissue constructs and provide an alternative mean to repair and regenerate damaged heart tissues. In this paper, we review the emerging directions associated with cardiac tissue engineering approaches. In particular, we discuss the use of hydrogels in repair and regeneration of damaged hearts. Because of their tissue-like biological, chemical and mechanical properties, hydrogels represent a potentially powerful material for directing cells into functional cardiac tissues. Herein, we will summarize both traditional and next-generation hydrogels with conductive, elastomeric and oxygen-releasing capabilities that can promote vascularization and stem cell differentiation to form properly functioning cardiac tissues.

引用

页码：e99 / e99

页数：12

共 105 条

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Interdigitated array of Pt electrodes for electrical stimulation and engineering of aligned muscle tissue [J].