Genetically modified animal models as tools for studying bone and mineral metabolism

被引：26

作者：

Davey, RA

MacLean, HE

McManus, JF

Findlay, DM

Zajac, JD

机构：

[1] Univ Melbourne, Dept Med, Heidelberg, Vic 3084, Australia

[2] Univ Adelaide, Dept Orthopaed & Trauma, Hanson Inst, Adelaide, SA, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 06期

关键词：

animal models; gene knockout/in; osteoblasts; osteoclasts; chondrocytes;

D O I：

10.1359/JBMR.040206

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic modification of mice is a powerful tool for the study of bone development and metabolism. This review discusses the advantages and disadvantages of various approaches used in bone-related research and the contributions these studies have made to bone biology.

引用

收藏

页码：882 / 892

页数：11

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