Regulatory T Cells: Key Players in Tolerance and Autoimmunity

被引：21

作者：

Chatila, Talal A. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Immunol Allergy & Rheumatol, Dept Pediat, Los Angeles, CA 90095 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2009年 / 38卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Regulatory T cells; Foxp3; Tolerance; Autoimmunity; IPEX; CD25; TGF-BETA; CUTTING EDGE; IMMUNE DYSREGULATION; TARGET GENES; FOXP3; EXPRESSION; TRANSCRIPTION; ACTIVATION; GENERATION; INDUCTION;

D O I：

10.1016/j.ecl.2009.01.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CD4 + CD25 + regulatory T (TR) lymphocytes are essential to the maintenance of immunologic tolerance in the host. The discovery of Foxp3 as a transcription factor essential to the differentiation of TR ushered in detailed studies of the molecular mechanisms of TR cell development, peripheral homeostasis, and effector functions. In humans, loss of function mutations in genes that regulate T-cell development and function have been associated with TR cell deficiency or dysfunction and syndromes of autoimmunity and immune dysregulation. Augmentation of TR cells by immunotherapy and pharmacologic agents is a promising strategy for the treatment of allergic and autoimmune diseases.

引用

收藏

页码：265 / +

页数：9

相关论文

共 51 条

[21] Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse [J].

Kamanaka, Masahito ;

Kim, Sean T. ;

Wan, Yisong Y. ;

Sutterwala, Fayyaz S. ;

Lara-Tejero, Maria ;

Galan, Jorge E. ;

Harhaj, Ed ;

Flavell, Richard A. .

IMMUNITY, 2006, 25 (06) :941-952

[22] An essential role for Scurfin in CD4+CD25+ T regulatory cells [J].

Khattri, R ;

Cox, T ;

Yasayko, SA ;

Ramsdell, F .

NATURE IMMUNOLOGY, 2003, 4 (04) :337-342

[23] Allergic dysregulation and hyperimmuno-globulinemia E in Foxp3 mutant mice [J].

Lin, W ;

Truong, N ;

Grossman, WJ ;

Haribhai, D ;

Williams, CB ;

Wang, JF ;

Martín, MG ;

Chatila, TA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (05) :1106-1115

[24] Regulatory T cell development in the absence of functional Foxp3 [J].

Lin, Wen ;

Haribhai, Dipica ;

Relland, Lance M. ;

Truong, Nga ;

Carlson, Marc R. ;

Williams, Calvin B. ;

Chatila, Talal A. .

NATURE IMMUNOLOGY, 2007, 8 (04) :359-368

[25] Foxp3 occupancy and regulation of key target genes during T-cell stimulation [J].

Marson, Alexander ;

Kretschmer, Karsten ;

Frampton, Garrett M. ;

Jacobsen, Elizabeth S. ;

Polansky, Julia K. ;

Maclsaac, Kenzie D. ;

Levine, Stuart S. ;

Fraenkel, Ernest ;

von Boehmer, Harald ;

Young, Richard A. .

NATURE, 2007, 445 (7130) :931-935

[26] The biology of interleukin-2 [J].

Matek, Thomas R. .

ANNUAL REVIEW OF IMMUNOLOGY, 2008, 26 :453-479

[27] Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10 [J].

Maynard, Craig L. ;

Harrington, Laurie E. ;

Janowski, Karen M. ;

Oliver, James R. ;

Zindl, Carlene L. ;

Rudensky, Alexander Y. ;

Weaver, Casey T. .

NATURE IMMUNOLOGY, 2007, 8 (09) :931-941

[28] Oral tolerance in the absence of naturally occurring Tregs [J].

Mucida, D ;

Kutchukhidze, N ;

Erazo, A ;

Russo, M ;

Lafaille, JJ ;

de Lafaille, MAC .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (07) :1923-1933

[29] IL-10-producing and naturally occurring CD4+ Tregs:: limiting collateral damage [J].

O'Garra, A ;

Vieira, PL ;

Vieira, P ;

Goldfeld, AE .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (10) :1372-1378

[30] Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 [J].

Ono, Masahiro ;

Yaguchi, Hiroko ;

Ohkura, Naganari ;

Kitabayashi, Issay ;

Nagamura, Yuko ;

Nomura, Takashi ;

Miyachi, Yoshiki ;

Tsukada, Toshihiko ;

Sakaguchi, Shimon .

NATURE, 2007, 446 (7136) :685-689

← 1 2 3 4 5 6 →