Bax-an emerging role in ectopic cell death

被引：17

作者：

Dicou, Eleni ^{[1
]}

Perez-Polo, J. Regino ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2009年 / 27卷 / 04期

关键词：

Bax; Ectopic primordial germ cells; Ectopic neurons; Cell death; PRIMORDIAL GERM-CELLS; OCCURRING NEURONAL DEATH; KNOCK-OUT MICE; NERVOUS-SYSTEM; MOUSE EMBRYO; PRECURSOR CELL; DEFICIENT MICE; GENE BAX; BCL-X; APOPTOSIS;

D O I：

10.1016/j.ijdevneu.2009.02.005

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

During embryonic and early postnatal development the combination of cell proliferation, migration, survival and cell death is intimately regulated. In the mouse embryo, significant numbers of primordial germ cells, the founder cells of the gametes, fail to migrate correctly to the genital ridges early in histogenesis. Studies in Bcl-2 associated X protein null mice (Bax(-/-)) have shown that the pro-apoptotic Bax gene is required for the programmed cell death of germ cells left in ectopic locations during and after germ cell migration. Independent studies carried out in the central nervous system of Bax(-/-) mice have shown impaired and ectopic neuronal migration in the cerebellum and olfactory bulb during development and in the adult hippocampus. Taken together, these evidences identify Bax as a major mechanism in ectopic cell death and are the subject of this review. (C) 2009 Published by Elsevier Ltd on behalf of ISDN.

引用

页码：299 / 304

页数：6

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