Functions of the MAPK family in vertebrate-development

被引：307

作者：

Krens, S. F. Gabby ^{[1
]}

Spaink, Herman P. ^{[1
]}

Snaar-Jagalska, B. Ewa ^{[1
]}

机构：

[1] Leiden Univ, Clusius Lab, Inst Biol, NL-2333 AL Leiden, Netherlands

来源：

FEBS LETTERS | 2006年 / 580卷 / 21期

关键词：

mitogen activated protein kinase; extracellular signal regulated protein kinase; c-Jun amino terminal MAPK; p38; development; vertebrates; zebrafish;

D O I：

10.1016/j.febslet.2006.08.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The mitogen activated protein kinase (MAPK) family, consisting of the extracellular signal regulated protein kinase, c-Jun amino terminal MAPK and p38 subfamilies, is conserved in evolution throughout the plant and animal kingdoms. These proteins have been implicated in diverse cellular processes including cell growth, migration, proliferation, differentiation, survival and development. Gene-targeting approaches in mice, chickens, frogs and zebrafish revealed crucial roles of MAPK in vertebrate development. Gene-disruption or -silencing often lead to lethal effects, therefore the zebratish ex utero development provides an excellent in vivo model to study the function of MAPK in early embryogenesis. In this review, we summarize the current understanding of the MAPK family function in vertebrate-development and place this into the perspective of possibilities for future research. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4984 / 4990

页数：7

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