Dimetallic hydrolases and their models

被引：131

作者：

Kimura, E ^{[1
]}

机构：

[1] Hiroshima Univ, Fac Med, Dept Med Chem, Minami Ku, Hiroshima 7348551, Japan

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(99)00076-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent mechanistic studies of Fe-3+/M2+ purple acid phosphatase present conflicting pictures about the roles of the metals. Recent model studies with Co3+/Co3+ and Fe3+/Fe3+ complexes have supported each conflicting mechanism for phosphate hydrolysis. With dizinc and trizinc complexes, the competitive binding of hydroxyl and phosphate substrates has been demonstrated.

引用

页码：207 / 213

页数：7

共 31 条

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