Metal-MACiE: a database of metals involved in biological catalysis

被引：63

作者：

Andreini, Claudia ^{[1
,2
]}

Bertini, Ivano ^{[1
,2
]}

Cavallaro, Gabriele ^{[1
,2
]}

Holliday, Gemma L. ^{[3
]}

Thornton, Janet M. ^{[3
]}

机构：

[1] Univ Florence, Magnet Resonance Ctr CERM, I-50019 Sesto Fiorentino, Italy

[2] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, Italy

[3] EBI, EMBL, Cambridge CB10 1SD, England

来源：

BIOINFORMATICS | 2009年 / 25卷 / 16期

基金：

英国惠康基金;

关键词：

IONS;

D O I：

10.1093/bioinformatics/btp256

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metal-MACiE is a new publicly available web-based database, held in MySQL, which aims to organize the available information on the properties and the roles of metals in the context of the catalytic mechanisms of metalloenzymes. Metal-MACiE, which currently covers 75% of metal-dependent enzyme commission (EC) sub-sub-classes and is continuously growing, exploits the existing MACiE database for the annotation of the reaction mechanisms. The two databases constitute complementary sources of information for enzymology, biochemistry and molecular pharmacology studies.

引用

收藏

页码：2088 / 2089

页数：2

相关论文

共 9 条

[1] Metal ions in biological catalysis: from enzyme databases to general principles [J].

Andreini, Claudia ;

Bertini, Ivano ;

Cavallaro, Gabriele ;

Holliday, Gemma L. ;

Thornton, Janet M. .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2008, 13 (08) :1205-1218

[2] BRENDA, AMENDA and FRENDA: the enzyme information system in 2007 [J].

Barthelmes, Jens ;

Ebeling, Christian ;

Chang, Antje ;

Schomburg, Ida ;

Schomburg, Dietmar .

NUCLEIC ACIDS RESEARCH, 2007, 35 :D511-D514

[3] Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitors [J].

Bateman, RL ;

Bhanumoorthy, P ;

Witte, JF ;

McClard, RW ;

Grompe, M ;

Timm, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (18) :15284-15291

[4] MDB: The metalloprotein database and browser at the scripps research institute [J].

Castagnetto, JM ;

Hennessy, SW ;

Roberts, VA ;

Getzoff, ED ;

Tainer, JA ;

Pique, ME .

NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :379-382

[5] Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli:: Evidence for optimal activation by nickel ions [J].

Clugston, SL ;

Barnard, JFJ ;

Kinach, R ;

Miedema, D ;

Ruman, R ;

Daub, E ;

Honek, JF .

BIOCHEMISTRY, 1998, 37 (24) :8754-8763

[6] PROMISE: a database of bioinorganic motifs [J].

Degtyarenko, KN ;

North, ACT ;

Findlay, JBC .

NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :233-236

[7] MACiE: a database of enzyme reaction mechanisms [J].

Holliday, GL ;

Bartlett, GJ ;

Almonacid, DE ;

O'Boyle, NM ;

Murray-Rust, P ;

Thornton, JM ;

Mitchell, JBO .

BIOINFORMATICS, 2005, 21 (23) :4315-4316

[8]

McDonald Andrew G, 2007, BMC Biochem, V8, P14, DOI 10.1186/1471-2091-8-14

[9]

Weatherburn DC, 2001, HANDBOOK ON METALLOPROTEINS, P193