Traffic-related air pollution exposure is associated with allergic sensitization, asthma, and poor lung function in middle age

被引：144

作者：

Bowatte, Gayan ^{[1
]}

Lodge, Caroline J. ^{[1
]}

Knibbs, Luke D. ^{[2
]}

Lowe, Adrian J. ^{[1
]}

Erbas, Bircan ^{[3
]}

Dennekamp, Martine ^{[4
]}

Marks, Guy B. ^{[5
,6
]}

Giles, Graham ^{[7
]}

Morrison, Stephen ^{[8
]}

Thompson, Bruce ^{[9
]}

Thomas, Paul S. ^{[10
]}

Hui, Jennie ^{[11
,12
,13
,14
]}

Perret, Jennifer L. ^{[1
]}

Abramson, Michael J. ^{[4
]}

Walters, Haydn ^{[15
]}

Matheson, Melanie C. ^{[1
]}

Dharmage, Shyamali C. ^{[1
,16
]}

机构：

[1] Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia

[2] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia

[3] La Trobe Univ, Sch Psychol & Publ Hlth, Dept Publ Hlth, Melbourne, Vic, Australia

[4] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia

[5] Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia

[6] Univ New South Wales, South Western Sydney Clin Sch, Sydney, NSW, Australia

[7] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[8] Royal Brisbane Hosp, Brisbane, Qld, Australia

[9] Alfred Hosp, Melbourne, Vic, Australia

[10] Univ New South Wales, Inflammat & Infect Res Ctr, Fac Med, Sydney, NSW, Australia

[11] Univ Western Australia, Busselton Populat Med Res Inst, Perth, WA, Australia

[12] Univ Western Australia, Sch Populat Hlth, Perth, WA, Australia

[13] Univ Western Australia, Sch Pathol & Lab Med, Perth, WA, Australia

[14] Sir Charles Gairdner Hosp, PathWest Lab Med WA, Perth, WA, Australia

[15] Univ Tasmania, Sch Med, NHMRC CRE, Hobart, Tas, Australia

[16] Murdoch Childrens Res Inst, Melbourne, Vic, Australia

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2017年 / 139卷 / 01期

基金：

英国医学研究理事会;

关键词：

Air pollution; allergic sensitization; asthma; Glutathione S-Transferase genes; respiratory function; S-TRANSFERASE P1; PARTICULATE; GENES; POLLUTANTS; SMOKING; ADULTS; ATOPY; FLOW;

D O I：

10.1016/j.jaci.2016.05.008

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Background: Traffic-related air pollution (TRAP) exposure is associated with allergic airway diseases and reduced lung function in children, but evidence concerning adults, especially in low-pollution settings, is scarce and inconsistent. Objectives: We sought to determine whether exposure to TRAP in middle age is associated with allergic sensitization, current asthma, and reduced lung function in adults, and whether these associations are modified by variants in Glutathione S-Transferase genes. Methods: The study sample comprised the proband 2002 laboratory study of the Tasmanian Longitudinal Health Study. Mean annual residential nitrogen dioxide (NO2) exposure was estimated for current residential addresses using a validated land use regression model. Associations between TRAP exposure and allergic sensitization, lung function, current wheeze, and asthma (n = 1405) were investigated using regression models. Results: Increased mean annual NO2 exposure was associated with increased risk of atopy (adjusted odds ratio [aOR], 1.14; 95% CI, 1.02-1.28 per 1 interquartile range increase in NO2 [2.2 ppb]) and current wheeze (aOR, 1.14; 1.02-1.28). Similarly, living less than 200 m from a major road was associated with current wheeze (aOR, 1.38; 95% CI, 1.06-1.80) and atopy (aOR, 1.26; 95% CI, 0.99-1.62), and was also associated with having significantly lower prebronchodilator and postbronchodilator FEV1 and prebronchodilator forced expiratory flow at 25% to 75% of forced vital capacity. We found evidence of interactions between living less than 200 m from a major road and GSTT1 polymorphism for atopy, asthma, and atopic asthma. Overall, carriers of the GSTT1 null genotype had an increased risk of asthma and allergic outcomes if exposed to TRAP. Conclusions: Even relatively low TRAP exposures confer an increased risk of adverse respiratory and allergic outcomes in genetically susceptible individuals.

引用

页码：122 / +

页数：9

共 40 条

[1]

Long-term exposure to air pollution and the incidence of asthma: meta-analysis of cohort studies [J].