The HIV-1 vaccine race

被引：50

作者：

Ho, DD ^{[1
]}

Huang, YX ^{[1
]}

机构：

[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

来源：

CELL | 2002年 / 110卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(02)00832-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is an urgent need to come up with a vaccine that will curtail the spread of HIV-1. To be successful, the scientific community must work in concert to develop sound strategies based on a deeper understanding of the virus. Significant technological advances are also required to overcome the unique obstacles posed by HIV-1. Some of the challenges we face in this endeavor are discussed here.

引用

页码：135 / 138

页数：4

共 11 条

[1] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].

Amara, RR ;

Villinger, F ;

Altman, JD ;

Lydy, SL ;

O'Neil, SP ;

Staprans, SI ;

Montefiori, DC ;

Xu, Y ;

Herndon, JG ;

Wyatt, LS ;

Candido, MA ;

Kozyr, NL ;

Earl, PL ;

Smith, JM ;

Ma, HL ;

Grimm, BD ;

Hulsey, ML ;

Miller, J ;

McClure, HM ;

McNicholl, JM ;

Moss, B ;

Robinson, HL .

SCIENCE, 2001, 292 (5514) :69-74

[2] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes [J].

Barouch, DH ;

Kunstman, J ;

Kuroda, MJ ;

Schmitz, JE ;

Santra, S ;

Peyerl, FW ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Gorgone, DA ;

Montefiori, DC ;

Lewis, MG ;

Wolinsky, SM ;

Letvin, NL .

NATURE, 2002, 415 (6869) :335-339

[3] HIV entry and its inhibition [J].

Chan, DC ;

Kim, PS .

CELL, 1998, 93 (05) :681-684

[4] AIDS - Diversity considerations in HIV-1 vaccine selection [J].

Gaschen, B ;

Taylor, J ;

Yusim, K ;

Foley, B ;

Gao, F ;

Lang, D ;

Novitsky, V ;

Haynes, B ;

Hahn, BH ;

Bhattacharya, T ;

Korber, B .

SCIENCE, 2002, 296 (5577) :2354-2360

[5] Viral dynamics of acute HIV-1 infection [J].

Little, SJ ;

McLean, AR ;

Spina, CA ;

Richman, DD ;

Havlir, DV .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (06) :841-850

[6] The quest for an AIDS vaccine:: is the CD8+ T-cell approach feasible? [J].

McMichael, A ;

Hanke, T .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (04) :283-291

[7] Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection [J].

Nowak, MA ;

Lloyd, AL ;

Vasquez, GM ;

Wiltrout, TA ;

Wahl, LM ;

Bischofberger, N ;

Williams, J ;

Kinter, A ;

Fauci, AS ;

Hirsch, VM ;

Lifson, JD .

JOURNAL OF VIROLOGY, 1997, 71 (10) :7518-7525

[8] GP120: Biologic aspects of structural features [J].

Poignard, P ;

Saphire, EO ;

Parren, PWHI ;

Burton, DR .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :253-274

[9] Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity [J].

Shiver, JW ;

Fu, TM ;

Chen, L ;

Casimiro, DR ;

Davies, ME ;

Evans, RK ;

Zhang, ZQ ;

Simon, AJ ;

Trigona, WL ;

Dubey, SA ;

Huang, LY ;

Harris, VA ;

Long, RS ;

Liang, XP ;

Handt, L ;

Schleif, WA ;

Zhu, L ;

Freed, DC ;

Persaud, NV ;

Guan, L ;

Punt, KS ;

Tang, A ;

Chen, MC ;

Wilson, KA ;

Collins, KB ;

Heidecker, GJ ;

Fernandez, VR ;

Perry, HC ;

Joyce, JG ;

Grimm, KM ;

Cook, JC ;

Keller, PM ;

Kresock, DS ;

Mach, H ;

Troutman, RD ;

Isopi, LA ;

Williams, DM ;

Xu, Z ;

Bohannon, KE ;

Volkin, DB ;

Montefiori, DC ;

Miura, A ;

Krivulka, GR ;

Lifton, MA ;

Kuroda, MJ ;

Schmitz, JE ;

Letvin, NL ;

Caulfield, MJ ;

Bett, AJ ;

Youil, R .

NATURE, 2002, 415 (6869) :331-335

[10] Modeling plasma virus concentration during primary HIV infection [J].

Stafford, MA ;

Corey, L ;

Cao, YZ ;

Daar, ES ;

Ho, DD ;

Perelson, AS .

JOURNAL OF THEORETICAL BIOLOGY, 2000, 203 (03) :285-301

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