Bulky nonproteinogenic amino acids permit the design of very small and effective cationic antibacterial peptides

被引：91

作者：

Haug, BE

Stensen, W

Stiberg, T

Svendsen, JS ^{[1
]}

机构：

[1] Univ Tromso, Dept Chem, N-9037 Tromso, Norway

[2] Lytix Biopharm AS, N-9037 Tromso, Norway

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 17期

关键词：

D O I：

10.1021/jm049582b

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The rate of multidrug-resistant infections is rapidly rising. Cationic antibacterial peptides are active against resistant pathogens and have low propensity for resistance development, but because of their unfavorable medicinal properties, cationic antibacterial peptides have been a limited clinical success. We have found that introduction of nongenetically coded amino acids and other lipophilic modifications opens the opportunity for development of extremely short and highly active antibacterial peptides with improved medicinal properties.

引用

页码：4159 / 4162

页数：4

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