Simple parameterization of non-proteinogenic amino acids for QSAR of antibacterial peptides

被引：15

作者：

Lejon, T ^{[1
]}

Svendsen, JS ^{[1
]}

Haug, BE ^{[1
]}

机构：

[1] Univ Tromso, Dept Chem, N-9037 Tromso, Norway

来源：

JOURNAL OF PEPTIDE SCIENCE | 2002年 / 8卷 / 07期

关键词：

pentadecapeptides; amino acids; antibacterial activity QSAR;

D O I：

10.1002/psc.403

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antibacterial activity of bovine lactoferricin-(17-31)-pentadecapeptide against Escherichia coli and Staphylococcus aureus is sensitive to substitution of the Trp residues, and synthetic peptides with phenylalanine and any of eight non-proteinogenic aromatic amino acids greatly affected antibiotic activity. Using simple size-related descriptors for the new amino acids it is possible to develop quantitative structure-activity relationships (QSARs) that can be used as tools in the search for more active peptides. Copyright (C) 2002 European Peptide Society and John Wiley Sons, Ltd.

引用

收藏

页码：302 / 306

页数：5

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