Blood-brain barrier interfaces and brain tumors

被引：50

作者：

Lee, SW

Kim, WJ

Park, JA

Choi, YK

Kwon, YW

Kim, KW ^{[1
]}

机构：

[1] Seoul Natl Univ, Neurovasc Coordinat Res Ctr, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Stroke & Neurovasc Regulat Lab, Boston, MA 02129 USA

[4] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Neuroprotect Res Lab, Boston, MA 02129 USA

[5] NIAID, Immunopathol Lab, Rockville, MD 20852 USA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2006年 / 29卷 / 04期

关键词：

blood-brain barrier; brain angiogenesis; barriergenesis; tight junctions; oxygen tension; glioblastoma;

D O I：

10.1007/BF02968569

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the developing brain, capillaries are differentiated and matured into the blood-brain barrier (BBB), which is composed of cerebral endothelial cells, astrocyte end-feet, and pericytes. Since the BBB regulates the homeostasis of central nervous system (CNS), the maintenance of the BBB is important for CNS function. The disruption of the BBB may result in many brain disorders including brain tumors. However, the molecular mechanism of BBB formation and maintenane is poorly understood. Here, we summarize recent advances in the role of oxygen tension and growth factors on BBB development and maintenance, and in BBB dysfunction related with brain tumors.

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页码：265 / 275

页数：11

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