High yielding synthesis of dehydroamino acid and dehydropeptide derivatives

被引:62
作者
Ferreira, PMT [1 ]
Maia, HLS [1 ]
Monteiro, LS [1 ]
Sacramento, J [1 ]
机构
[1] Univ Minho, Dept Chem, P-4700320 Braga, Portugal
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 24期
关键词
D O I
10.1039/a904730a
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
By using a 4-dimethylaminopyridine (DMAP) catalysed reaction of beta-hydroxyamino acid derivatives with tert-butyl pyrocarbonate [(Boc)(2)O], dehydroamino acid derivatives are obtained in high yields. The same methodology applied to dipeptides with a beta-hydroxyamino acid residue gives the corresponding dipeptides with a dehydroamino acid residue.
引用
收藏
页码:3697 / 3703
页数:7
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